Selected Portfolio Companies
Biotech – Neurodegeneration and Psychiatry
AZTherapies is a biopharmaceutical company with a novel combination drug regimen to address the neuroinflammatory component of Alzheimer's disease.
Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease. Cajal is inspired by the pioneering work of Nobel laureate Santiago Ramón y Cajal who illuminated the complexity of the brain by marrying art and science.
Cerevance is a clinical-stage pharmaceutical company focused on brain diseases that is applying a new technology, called NETSseq, to reveal transcriptional and epigenetic differences between specific cell types in mature human brains. By applying its technology to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance is identifying targets and advancing a pipeline of novel therapeutics that modulate them for CNS diseases.
Delix Therapeutics is based on the discovery of a novel class of neuroplasticity-promoting therapeutics known as psychoplastogens. Delix is building a world class CNS company on a mission to broaden patient access to safe, fast-acting, and long-lasting medicines for mood disorders.
Libra Therapeutics is developing novel disease-modifying therapeutics that can restore the cellular balance disrupted in neurodegenerative diseases such as ALS, FTD and Alzheimer's. Libra's platform is uniquely positioned to discover small molecules with distinct molecular approaches that can 1) increase autophagy to more rapidly clear toxic proteins and 2) attenuate the production of neurotoxic proteins.
NeuroTherapia is developing new chemical entities targeting CB2 receptors on microglia, significantly reducing the expression of inflammatory agents resulting in neuronal survival and proliferation.
Paros Bio is creating a gene therapy to treat Autosomal Dominant Alzheimer's Disease caused by mutations in PSEN1.
PharmatrophiX is focused on the development of disease-modifying small molecule drugs, discovering & developing small molecule Neurotrophin pathway modulators.
QurAlis is bringing hope to the ALS community by developing breakthrough precision medicines for this devastating disease. Our stem cell technologies generate proprietary human neuronal models that enable us to more effectively discover and develop innovative therapies for genetically validated targets.
Therini Bio is a vascular biology company focused on developing novel therapies based on a deep understanding of fibrin and its role in driving pathological inflammatory processes.
Tiaki Therapeutics has developed a proprietary in vitro microglia platform for the discovery of new microglial functions in dementias and has found a way to regulate and restore homeostatic function for the treatment of dementia.
Athira Pharma is a therapeutics company that has a novel platform of disease-modifying regenerative small molecules, particularly relevant to neurodegenerative diseases with a focus on Alzheimer’s. Athira is publicly traded since 2020 (NASDAQ: ATHA). Co-investors included Sofinnova Investments, Viking Global, Franklin Templeton, Janus Henderson Investors, Alzheimer’s Drug Discovery Foundation, and W Fund.
Cognition Therapeutics is a biopharmaceutical company developing small-molecule therapeutics that address the toxic oligomeric proteins that cause membrane trafficking dysfunction, triggering neurodegenerative diseases such as Alzheimer’s disease. Cognition Therapeutics is publicly traded since 2021 (NASDAQ: CGTX). Co-investors included Golden Seeds, Ogden Capital and the National Institute of Aging.
Cortexyme is developing novel treatments for altering the course of Alzheimer's and other neurological diseases. The platform is based on a new theory of the cause of Alzheimer's, targeting a specific, undisclosed pathogen tied to neurodegeneration. Cortexyme is publicly traded since 2019 (NASDAQ: CRTX). Co-investors included Pfizer Ventures, Takeda Ventures, Sequoia Capital, Breakout Labs, Breakout Ventures, Verily Life Sciences, EPIQ Capital Group, the Lamond Family and Vulcan Capital.
Tetra Therapeutics is a clinical stage company developing a platform of pharmaceutical therapies targeting Type 4 phosphodiesterases (PDE4) enzymes in multiple neurological conditions including Fragile X Syndrome, Alzheimer’s Disease, Traumatic Brain Injury (TBI), Multiple Sclerosis (MS), and Chronic Traumatic Encephalopathy (CTE). The company was acquired by Shinogi in 2020. Co-investors included Apjohn Group, Johnson & Johnson, Grand Angels and the Alzheimer’s Drug Discovery Foundation.
Yumanity Therapeutics is taking a new approach to neurodegenerative disease drug discovery and development by correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes. Yumanity is publicly traded since 2020 (NASDAQ: YTMX). Co-investors included Alexandria Venture Investments, Sanofi Ventures and Redmile Group.
Life Sciences – Medical Device and Technology Platforms as Tools to Accelerate Biomedical Research, Drug Development and Clinical Trials
Acrigen Biosciences is building a pipeline of therapies to treat genetic disorders using their proprietary CRISPR-Cas gene editors coupled with anti-CRISPR proteins to improve the precision, efficacy, and safety of genetic therapies.
Aether repurposes enzymes to create new compounds and manufacturing process by utilizing a high-throughput robotic laboratory.
Alzeca Biosciences develops novel, targeted Magnetic Resonance (MR) imaging agents for the early detection and diagnosis of Alzheimer’s Disease and other neurodegenerative diseases. An MRI based approach has a significantly lower cost, is widely available around the world, and has no radiation.
Atomwise neural network technology, called AtomNet, evaluates digital libraries of chemical compounds in search of novel small molecules to improve screening and accelerate the drug discovery process.
Bionaut Labs is developing a computer-guided, micro-robotic platform to revolutionize the treatment of central nervous system (CNS) diseases and disorders.
Cala Health is a bioelectronic medicine company transforming the standard of care for chronic disease such as Essential Tremor. Cala’s wearable neuromodulation therapies merge innovations in neuroscience and technology to deliver individualized peripheral nerve stimulation.
Canaery neural interface technology leverages the superior sense of smell in animal models to detect and digitize the world of scent.
Cogstate computerized cognitive assessment technology delivers highly sensitive measures of cognition for clinical trials, healthcare diagnostics, academic research and brain injury. These validated cognitive tests are the center of Cogstate solutions for recruiting and screening clinical trial participants (Precision Recruitment™), measuring drug safety and efficacy endpoints (Cogstate Clinical Trials™), and tools to detect cognitive change in patients (COGNIGRAM®). Cogstate Rater Services provide expert rater training and monitoring support to minimize human error in traditional paper-and-pencil cognitive tests in clinical trials. Cogstate is publicly traded (ASX: CGS).
Cytovale is a medical device company that has developed an innovative approach for early detection of sepsis.
Enclear Therapies medical device clears the cerebrospinal fluid of toxic proteins to treat neurodegenerative diseases.
Envisagenics applies computational biology with RNA-sequencing to accelerate pharmaceutical candidate selection and biomarker development.
Genemod laboratory workflow software manages scientific protocols, inventory and ensures robust data security and indexing to improve collaboration, throughput, and quality control.
GenomSys utilizes an ISO-compliant format, MPEG-G, to standardize genomic data, enabling interoperability and efficient processing of genetic information.
Herophilus is a neurotherapeutics platform company that is developing organoid disease models to discover novel drugs for neurological disorders.
Paradromics neural interface technologies will deliver high-volume, bidirectional data streaming capabilities between brains and computers, initially targeting applications to assist physically disabled patients.
Salvia BioElectronics is developing a minimally invasive neurostimulation therapy for people suffering from chronic migraine.
Strateos automates chemistry and biology processes, coupled with tissue analysis, in a closed-loop robotic laboratory to accelerate science and drug discovery. The company was formed in June 2019 as a result of a merger between 3Scan and Transcriptic.
Switch Therapeutics is a venture backed startup company developing a new generation of RNAi therapies based on revolutionary technology developed at Caltech, City of Hope and Harvard Medical School.
Basis Science developed the world’s most advanced wearable health tracker. The company was acquired by Intel in 2014. Co-investors included Mayfield Fund, Norwest Venture Partners, DCM, Intel Capital.
Echo Laboratories has developed table-driven bright field and fluorescent hybrid microscopes supporting both upright and inverted formats with proprietary cloud-connected software to improve imaging, analysis, and collaboration. The company was acquired by Cellink in 2021. Co-investors included Tech Coast Angels.
goBalto develops next-generation solutions that simplify and accelerate clinical study startup in the pharmaceutical, biotechnology, and medical device industries. With a proven commitment to customer success, disruption, and optimization, GoBalto is changing the way global pharma and CRO approach business processes. The company was acquired by Oracle in 2018. Co-investors included Aberdare Ventures, Qualcomm, EDBI and Mitsui.
Hyperfine Research The Hyperfine Swoop is an FDA approved portable MRI system introducing novel hardware and software to improve access and affordability. The company is publicly traded since 2021 (NASDAQ: HYPR). Co-investors included GV and 4Catalyzer.
Vium empowers biomedical investigators with technology that accelerates the preclinical drug discovery and development pipeline. Researchers can design, run, and analyze experiments that rapidly surface insights and high volumes of quality data while improving the speed and reproducibility of preclinical research. The company was acquired by Recursion in 2020. Co-investors included Lux Capital, DCVC, Founder's Fund, and AME Cloud Ventures.
Zebra Medical Vision applies computer vision and machine learning to medical imaging records to understand the risk profile of patients, detect and predict disease and assist in building and managing preventative care programs. The company was acquired by Nanox in 2021. Co-investors included Khosla Ventures, Marc Benioff, Intermountain Investment Fund, OurCrowd Qure, Aurum, aMoon, Nvidia, Johnson & Johnson.
IT Software, Infrastructure, and Security
AccuKnox simplifies the process of securing IT workloads against vulnerabilities, supply chain issues, misconfigurations and malicious adversaries with continuous security observability, zero trust policy management and real-time monitoring.
AuthenticVision develops technologies for brand protection and real-time marketing with mobile applications for the identification of counterfeit goods. The core technology was developed at the University of Applied Science, Salzburg, Austria.
Bleximo application-focused super conducting computers revolutionize the way complex scientific and business problems are solved.
Cato Digital provisions Software-Defined Power to Data Centers via intelligent and automated power provisioning to server farms. Cato Digital technology increases reliability, reduces power losses and simplifies the power infrastructure across the industry.
Lynkstate performance measurement and analysis optimizes network performance across cloud and client.
MedCrypt healthcare cybersecurity for medical devices cryptographically secures patient data, monitors device vulnerability and behavior, intrusion detection, and access control to ensure the safest care delivery while allowing manufacturers to rapidly deploy and innovate clinical features.
Moove.ai connected vehicle and roadway data insights improve transportation safety and efficiency
NativeWaves allows viewers to select multiple perspectives for live events via mobile device.
Roviero native graph processor system architecture enables a fully programmable neural network engine for edge AI computing.
TripleBlind enterprise digital privacy as a service enables companies to safely leverage extremely sensitive data and algorithms in encrypted space.
Vorticity custom silicon accelerators enable exceptionally fast scientific computing on the cloud.
Keyssa is the next generation wireless connector, capable of 6 Gigabits per second delivered across a secure, protocol agnostic EHF transmission. The company was acquired by Molex in 2021. Co-investors included Alsop Louis Partners, Samsung Catalyst Fund, and Intel Capital.
Podium Data enables businesses to rapidly consolidate all their data into manageable Hadoop-based data lakes for faster, more effective analytics and insights. The company was acquired by Qlik in 2018.
SST ShotSpotter Technology is a gunfire detection system of acoustic sensors and analytics to precisely locate gunfire across urban and rural environments for law enforcement, homeland security, private security, and military markets. ShotSpotter is publicly traded since 2017 (NASDAQ: SSTI). Co-investors included Lauder Partners, Levensohn Venture Partners, Claremont Creek, City Light, and Labrador Ventures.
Wickr is a communications platform backed by multi-layer encryption that provides private and untraceable transmission, delivery, and storage across any medium (email, messaging, video, and social media.) The technology can be overlaid on existing network platforms and has the potential to become the go-to application for safe and secure communication amongst corporate/government enterprises, gaming, and personal accounts. The company was acquired by Amazon in 2021. Co-investors included Alsop Louie Partners, Breyer Capital, CME Ventures, Juniper Networks and Singtel Innov8.
all.health helps detect lifestyle diseases and manage existing conditions to affect health outcomes.
Atmosic wireless technology improves radio performance and battery life for IoT and connected device applications.
Sea Machines autonomous navigation, collision avoidance, and remote command for the commercial maritime sector improves safety and productivity for survey ships, patrol boats, ferries and workboats.
August builds products that make life simpler, allowing physical environments to seamlessly respond to user behavior. The August Smart Lock, the company’s flagship product, provides secure access to the home by controlling who can and cannot enter, without the need for keys or codes, managed through your smartphone. The company was acquired by Assa Abloy in 2017. Co-investors included Maveron, Bessemer Venture Partners, Comcast Ventures and Qualcomm Ventures.
Eargo is an audio hardware company revolutionizing the hearing experience. Eargo is publicly traded since 2020 (NASDAQ: EAR). Co-investors included Maveron, New Enterprise Associates, Nan Fung Life Sciences, and Glide Capital.
Motiv Ring performs high performance health monitoring and analytics for exercise, sleep, and daily living. The company was acquired by Proxy in 2020. Co-investors included Kleiner Perkins, AME Cloud, and SOSV.
Noon Home lighting controls deliver intelligent automation and enable creative scenes and layered lighting for residential and commercial lighting. The company was acquired by RacePoint Energy in 2020. Co-investors included Shasta Ventures, Lux Capital and Sway Ventures.
Integral Reality Labs bridges the physical and digital world of gaming and creative media through 3D printing and tokenized data. IRL’s cloud-based tools heal 3D models, and enable frame-accurate 3D printable content creation derived from gaming and other media. IRL models can be minted as NFT’s while preserving behavioral data to interact with other smart collectibles and smart surfaces across the metaverse and physical environments.
New Matter was founded in 2014 with a mission to bring 3D printing to every home, school, and office through its flagship product, the MOD-t. Slated for release in late 2015, the MOD-t will be one of the most affordable 3D printers on the market and will be integrated with New Matter’s online store of 3D printable designs, allowing users of all skill levels to find, customize, and print great objects.
Icon Aircraft is redefining the small aircraft experience for pilots of all age and experience levels with the Icon A5 amphibious light sport aircraft.
OKAPI:Orbits telemetry, navigation and flight control guidance software for in-orbit satellites ensures safe flight in space. The company also provides support for program planning and forecasting to minimize downtime in increasingly-crowded regions of orbit.
Phase Four plasma propulsion systems improve navigation and efficiency for in-orbit satellite missions.
Source Energy Company is operating in stealth mode.
Stellar Labs aviation marketplace provides a new experience for procuring private aircraft charter with real-time price quotes while helping operators optimize their fleet.
Ubotica on-board AI edge processing transforms satellite services and data processing.
Ursa Major Technologies manufactures propulsion systems for micro- and nano-satellite launch vehicles.
Virtual Reality and Augmented Reality
8i is transforming video capture and playback to deliver a new medium for all display devices.
DigiLens holographic optical waveguide technology and material science delivers unique optical solutions for display and imaging applications. Digilens is a leader in Switchable Bragg Grating (SBG) technologies.
Mojo Vision contact lens wearable video display enables personal mobile computing and augmented vision.
Niantic Labs is a mobile software company focused on location-based augmented reality games. The company’s first title, Pokémon Go, launched in July 2016.
UltraLeap uses ultrasound waves to build touchless and gesture-based user interfaces that provide tactile sensations with mid-air virtual objects.
AltSpaceVR is a virtual reality software company bringing two-dimensional web content into shared virtual spaces and extending the web to create fully holographic experiences. The company was acquired by Microsoft in 2017. Co-investors included Tencent, GV, Formation 8 and Comcast Ventures.
Chirp Microsystem ultrasonic transceivers generate real-time 3D depth mapping for AR/VR, drones, and Connected Devices. The company was acquired by TDK in 2018.
Eyefluence embedded systems translate intent into action through human eye-driven UI/UX technologies for head mounted displays (HMDs). The company was acquired by Google in 2016. Co-investors include Jazz Ventures Partners, Intel Capital and Motorola Solutions Venture Capital.
Lightform creates simple, powerful tools that connect the real and digital worlds through computer vision and projected augmented reality.
Materials Science and Manufacturing Sustainability
Diamond Age full stack software-driven construction automation technology aims to improve quality, speed and cost for building construction.
H2U Technologies end-to-end ultra-high throughput catalyst discovery platform for hydrogen generation and fuel cells.
Kuprion nanocopper pastes and inks provide higher performance alternatives to lead free solder, AuSn, and NanoSilver for electronic components and assemblies.
Sepion Technologies nano-porous membrane technology increases lithium ion battery performance.
Sharrow Marine is a nautical and aeronautical design firm specializing in high performance propulsion. The Sharrow Propeller improves performance and efficiency while reducing noise, vibration, and cavitation across all marine propulsion applications.
Twelve applies electrochemical processes to recycled industrial waste products, starting with CO₂ , to efficiently produce useful chemicals and fuels.
Phylagen technology identifies supply chain sources using the environmental microbiome.
Plethora technology provides on-demand CNC machining design analysis, estimating, and fulfillment of high-quality custom prototypes and end-production parts.
Tempo Automation’s connected factory is the world's fastest printed circuit board assembly (PCBA) manufacturing service, powered by proprietary automation software, creating an unbroken digital thread from design to delivery for rapid prototyping, high-volume design optimization, as well as low-volume high-precision runs. Tempo Automation is publicly traded since 2022 (NASDAQ: TMPO). Co-investors included Lux Capital, Point72 Ventures, Bolt and AME Cloud Ventures